Foscavir foscarnet sodium injection side effects, images. Ten percent to 28% of the cumulative dose may have been deposited in bone 2 days after. After binding, the drug blocks the cleavage of the pyrophosphate moiety from deoxynucleotide triphosphates, in turn halting dna chain. Due to the potential for serious toxicities in a nursing infants, breastfeeding should be avoided during foscarnet therapy. Jul 22, 2019 foscarnet sodium is a white, crystalline powder containing 6 equivalents of water of hydration with a molecular formula of na 3 co 5 p6 h 2 o and a molecular weight of 300. Buy foscavir foscarnet sodium online blink health rx. Foscarnet sodium definition of foscarnet sodium by the. Finished dosage form formulation imports of foscarnet sodium into india, obtained from trade importexport statistics. Foscarnet is injected into a vein through an iv using an infusion pump.
Foscarnet trisodium phosphonoformate is a pyrophosphate analog that has been shown to be effective in the initial treatment of cmv infection as well as for infections caused by other herpes family viruses in patients undergoing renal and bone marrow transplantation. Ganciclovir, foscarnet, and cidofovir are antiviral drugs approved for use against cytomegalovirus cmv in adults by the us food and drug administration. Drug interactions and toxicities associated with the. Find medication information including related drug classes, side effects, patient statistics and answers to frequently asked questions.
Foscavir is an organic analogue of inorganic pyrophosphate that inhibits replication of herpes viruses. If youre looking to insert the contents of your pdf file into an office file, as opposed to simply inserting the pdf as an attachment, then your best bet is to open that pdf with word 20 or 2016. Foscavir contains sodium foscavir contains 240 micromoles 5. Pdf pharmacokinetics and absorption of foscarnet after. Sep 01, 2010 cytomegalovirus cmv, a member of the herpesviridae family, may be transmitted via solid organ or hematopoietic stem cell transplantation as well as through saliva, sexual contact, placental transfer, breastfeeding, or blood transfusion. Jan 10, 2019 store foscarnet sodium injection at room temperature, 68f to 77f 20c to 25c, and protect it from excessive heat and from freezing. You may receive foscarnet injection in a hospital or you may administer the medication at home. Due to sodium content of foscarnet 240 micromoles 5. Foscarnet sodium has the potential to chelate divalent metal ions, such as calcium and magnesium, to form stable coordination compounds. Foscarnet is used to treat cytomegalovirus cmv retinitis in people with aids. Read all of this leaflet carefully before you start. Based on these observations, it is necessary to modify the dosage of foscarnet in patients with renal impairment see dosage and. Foscavir foscarnet sodium injection, solution ndc codes.
Foscarnet should be administered by the intravenous route only, either by a central venous line or in a peripheral vein. Foscarnet sodium has been associated with changes in serum electrolytes including hypocalcemia, hypophosphatemia, hyperphosphatemia, hypomagnesemia, and hypokalemia. These dosage recommendations are approximate and actual dosing should always be based on the clinical situation. Foscavir is also indicated for the treatment of mucocutaneous herpes simplex virus. Common adverse reactions include fever, nausea, diarrhea, anemia, abdominal pain,hypokalemia, coughing, dyspnea,confusion, anxiety. The publishers final edited version of this article is available at biochemistry. Foscavir 24 mgml solution for infusion summary of product. This medication is an antiviral that works by stopping the growth of viruses.
Foscarnet is sometimes combined with another antiviral drug, ganciclovir, when the cmv infection does not respond to either drug used alone for treatment. Foscarnet sodium is an antiviral medication that is fda approved for the treatment of cmv retinitis, mucocutaneous acyclovir resistant hsv infections. Effects of acyclovir, foscarnet and ribonucleotides on herpes. Efficacies of topical formulations of foscarnet and acyclovir and of. The penetration of foscarnet into csf, as expressed by the ratio of the concentration in csf to the simultaneous concentration in plasma, ranged from 0 to 3. Foscavir is indicated for induction and maintenance therapy of cytomegalovirus cmv retinitis in patients with aids. Foscarnet selectively blocks the pyrophosphate binding site of virusspecific dna polymerases at concentrations that do not affect cellular dna polymerases. Foscarnet and ganciclovir combination therapy for cmv. Foscarnet is usually given for hsv after other antiviral medications have. Since the dose of foscarnet sodium is calculated on the basis of body. Not determined relevant identified uses of the substance or mixture and uses advised against intended use. Foscarnet injection comes as a liquid to be intravenously into a vein.
Cytomegalovirus cmv, a member of the herpesviridae family, may be transmitted via solid organ or hematopoietic stem cell transplantation as well as through saliva, sexual contact, placental transfer, breastfeeding, or blood transfusion. It binds reversibly near the pyrophosphatebinding site of dna polymerase or reverse transcriptase without requiring further modification 1. They have a broad spectrum of antiviral activity and are accordingly used for treatment of. Even patients with serum creatinine in the normal range may require dose adjustment. The length of your treatment depends on how you respond to the medication. An antiviral drug, cna3o5p, used intravenously to treat herpesvirus infections, especially cytomegalovirus retinitis. Foscavir tm foscarnet sodium injection hospira inc. Based on these observations, it is necessary to modify the dosage of foscarnet in patients with. It is usually infused slowly over 1 to 2 hours every 8 or 12 hours. Mar, 2017 foscarnet is injected into a vein through an iv using an infusion pump.
Nov 09, 2018 foscarnet is injected into a vein through an iv using an infusion pump. Keep foscarnet sodium in the container that it came in and keep the container tightly closed. Individually dispensed doses of foscarnet should be aseptically transferred and diluted with equal parts of 0. It is classified as a pyrophosphate analog dna polymerase inhibitor. Foscarnet api manufacturers suppliers pharmacompass. Foscarnet is the conjugate base of a chemical compound with the formula ho 2 cpo 3 h 2.
This medication is given by injection into a vein by a health care professional in a hospital or clinic setting. Foscarnet was administered intravenously at various dosages at 12h intervals. For intravenous infusion foscavir, give intermittently in glucose 5% or sodium chloride 0. When peripheral veins are used, the solution of foscarnet 24 mgml must be diluted. Foscarnet sodium is a white, crystalline powder containing 6 equivalents of water of hydration with an empirical formula of na 3 co 5 p6 h 2 o and a molecur weight of 300. Foscarnetfoscavir generic is an antiviral medication, prescribed for cytomegalovirus cmv retinitis in patients with acquired immunodeficiency syndrome aids and resistant herpes simplex virus.
Foscarnet phosphonomethanoic acid, known by its brand name foscavir, is an antiviral medication which is primarily used to treat viral infections involving the herpesviridae family. Foscarnet definition and meaning collins english dictionary. No information is available on levels of foscarnet which may appear in human breast. Foscavir fda prescribing information, side effects and uses. Due to inconsistencies between the drug labels on dailymed and the pill images provided by rximage, we no longer display the rximage pill images associated with drug labels we anticipate reposting the images once we are able identify and filter out images that do not match the information provided in. Foscarnet is the conjugate base of a chemical compound with the formula ho 2 cpo 3 h 2 foscarnet was approved for medical use in 1991. Controlling cmv retinitis can help decrease the risk of blindness from the infection. There is a black box warning for this drug as shown here. Ganciclovirresistant cytomegalovirus cmv is associated with significant.
Appropriate studies have not been performed on the relationship of age to the effects of foscarnet injection in the pediatric population. A healthcare provider will show you how to use an infusion pump. Based on these observations, it is necessary to modify the dosage of foscarnet in patients with renal impairment see dosage. Foscavir injection, phosphonoformic acid foscarnet.
This drug is also effective against acyclovirresistant hsv and varicellazoster. This medication is not a cure for cmv or hsv diseases. Foscarnet sodium dosing must be individualized according to the patients renal function status. View import data from india, price, monthly trends, major countries, major ports for foscarnet sodium finished dosage formulations finished dosage form formulation imports of foscarnet sodium into india, obtained from trade importexport statistics. Foscarnet sodium definition of foscarnet sodium by the free.
Pharmaceutical active used as antiviral details of the supplier of the safety data sheet 2. Due to the potential for serious toxicities in a nursing infants, breastfeeding should be avoided during foscarnet therapy until further clarification of the risk has been made. Foscarnet sodium is not recommended in patients undergoing hemodialysis because dosage guidelines have not been established. Foscarnet sodium drug bnf content published by nice. Foscarnet definition of foscarnet by the free dictionary. Foscarnet sodium injection foscavir side effects, medical. All currently available anticmv drugsincluding ganciclovir, foscarnet, and cidofovirtarget the viral dna polymerase. Foscavir foscarnet sodium injection product insert rubber latex has not been used in the manufacture of this device or drug container closure. Foscarnet is also used to treat herpes simplex virus hsv in people with a weak immune system. Reactions were initiated by adding enzyme typically 50 nm and.
Foscavir foscarnet sodium this product information is intended only for residents of the united states. Foscavir foscarnet sodium dose, indications, adverse. Foscarnet is a synthetic organic analog of inorganic pyrophosphate with activity against several types of viruses, but primarily used for the treatment of cytomegalovirus retinitis. Ganciclovir, valganciclovir, foscarnet, and cidofovir. Foscarnet trisodium phosphonoformate is a pyrophosphate analog. Iv induction 60 mgkg infused over 1 h q8h for 23 wk. See how to insert a file in pdf format into your office file as an attachment. Foscarnet is used for the treatment of invasive cmv disease among patients with suspected or documented ganciclovirresistant cmv. You can resize the object, but you cant edit it after you insert it. Oral probenecid was administered at a dosage of 2 grams, 1 hour prior to. This medication is also used to treat herpes infections hsv that do not respond to treatment with acyclovir acyclovirresistant.
How to have foscavir foscavir will be given to you by a doctor or nurse. Animal studies have shown that foscarnet distributes into breast milk at concentrations that are three times greater than maternal plasma concentrations. Hydrochloric acid may have been added to adjust the ph of the solution to 7. Careful attention to dosing is required given the doserelated toxicities of foscarnet. Foscarnet definition of foscarnet by medical dictionary.
This drug is also effective against acyclovir resistant hsv and varicellazoster. The medicine enters the body through a catheter placed into the vein. Word will convert the pdf to editable text and you can then copy and paste that text into your office document. Foscarnet indications, dosage, side effects and precautions. Foscarnet foscavir generic is an antiviral medication, prescribed for cytomegalovirus cmv retinitis in patients with acquired immunodeficiency syndrome aids and resistant herpes simplex virus. Penetration of foscarnet into cerebrospinal fluid of aids. Foscarnet fda prescribing information, side effects and uses. Why is dailymed no longer displaying pill images on the search results and drug info pages. Foscarnet is an antiviral medicine that prevents certain viruses from multiplying in your body.
As of 20, this field contains the consumer friendly descriptions for the ama cpt codes. Resolution of mild ganciclovirresistant cytomegalovirus disease. Feb 21, 2019 foscarnet trisodium hexahydrate 24 mgml. Foscarnet sodium finished formulations import data. For nonprescription products, read the label or package ingredients carefully. Careful personal hygiene is recommended after urination to lessen the potential for local irritation. Refer to table below for recommended doses and adjust the dose as indicated. The disposition of foscarnet could be explained by a triexponential equation t12 lambda 1, 0. Similarly, ganciclovir as the biologically active gcvtp primarily functions as a. This ed material has been downloaded from a licensed data provider and is not for distribution, except. View detailed import data, price, monthly trends, major importing countries, major ports of foscavir. Add a pdf to your office file office support microsoft office support. Assessment 20182028 by drug type based on drug type market analysis, the cytomegalovirus treatment market is segmented into ganciclovir, valganciclovir, foscarnet, cidofovir.
Do not use foscarnet sodium if the original seal over the container opening is broken or missing. Concentrations in plasma and csf at the end of foscarnet infusion or 1, 3, 5, 6, and 12 h after infusion were determined by highperformance liquid chromatography. Artesunate as a potent antiviral agent in a patient with late drug. Foscarnet side effects, dosage, interactions drugs. Selected from data included with permission and ed by first databank, inc. Foscarnet solution for injection drug information, side. Do not selfinject foscarnet if you do not understand how to give the injection and properly dispose of used needles, iv tubing, and other. Foscarnet and ganciclovir combination therapy for cmv disease. The chemical name of foscarnet sodium is phosphonoformic acid, trisodium salt. In seven episodes of gastrointestinal disease five colitis, two esophagitis remission of symptoms and mucosal changes was achieved in five. Renal clearance accounted for most of the plasma clearance, the difference probably reflecting the passage of foscarnet into bone. This should be taken into consideration by patients on a controlled sodium diet, so please tell your doctor or nurse if you are on a low sodium salt diet. Foscarnet sodium is a white, crystalline powder containing 6 equivalents of water of hydration with an empirical formula of na 3 co 5 p6 h 2 o and a molecular weight of 300.
Foscarnet does not require activation phosphorylation by thymidine kinase or other kinases and therefore is active in vitro against hsv tk deficient mutants and cmv ul97 mutants. The long terminal phase elimination halflife of foscarnet up to mean 88 hours is assumed to be the result of sequestration of the drug into bone, but the shorter first and second phase halflives up to 1. This medication is used to control cytomegalovirus cmv eye infections cmv retinitis in persons with aids. Cmvigg was provided as an adjunct to antiviral therapy, as well as for its. Pdf penetration of foscarnet into cerebrospinal fluid of. Foscarnet is an organic analogue of inorganic pyrophosphate that inhibits replication of herpes viruses in vitro including cytomegalovirus cmv and herpes simplex virus types 1 and 2 hsv1 and hsv2. The topical efficacies of foscarnet and acyclovir incorporated into a. Foscarnet intravenous route before using mayo clinic. Foscarnet sodium may also be associated with a doserelated decrease in ionized serum calcium which may not be reflected in total serum calcium.
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